High-cost drugs
Last updated on September 8, 2026This page contains the current and the deleted list of designated high-cost drugs and their allowable markup.
On this page
For further details, visit the High-Cost Drugs Policy — Section 5.8, PharmaCare Policy Manual
Current list
An asterisk (*) indicates the most recent addition(s). Deletions are listed at the end.
| DIN/PIN | Chemical Description | Product Name | Allowable Markup | Effective Date |
|---|---|---|---|---|
| 02402475 | abatacept 125 mg/mL pre-filled syringe | Orencia® | 5% | 2014-04-01 |
| 02282097 | abatacept 250 mg vial | Orencia® | 5% | 2011-04-01 |
| 02528363 02528371 02528398 |
abrocitinib 50 mg tablet abrocitinib 100 mg tablet abrocitinib 200 mg tablet |
Cibinqo® | 5% | 2023-11-28 |
| 02511061* 02511053* 02511045* |
adalimumab 20 mg/0.4 mL pre-filled syringe adalimumab 40 mg/0.8 mL pre-filled syringe adalimumab 40 mg/0.8 mL pre-filled pen |
Abrilada™ | 5% | 2022-08-18 |
| 02459310 02459299 02459302 |
adalimumab 20 mg/0.4 mL pre-filled syringe adalimumab 40 mg/0.8 mL pre-filled syringe adalimumab 40 mg/0.8 mL autoinjector |
Amgevita™ | 5% | 2021-04-07 |
| 02533472 | adalimumab 40 mg/0.4 mL pre-filled syringe | Hadlima® | 5% | 2023-12-19 |
| 02473097 02473100 |
adalimumab 40 mg/0.8 mL pre-filled syringe adalimumab 40 mg/0.8 mL autoinjector |
Hadlima® | 5% | 2021-04-07 |
| 02533480 | adalimumab 40 mg/0.4 mL autoinjector | Hadlima® PushTouch® | 5% | 2023-12-19 |
| 02502380* | adalimumab 20 mg/0.4 mL pre-filled syringe | Hulio® | 5% | 2022-08-18 |
| 02502399 | adalimumab 40 mg/0.8 mL pre-filled syringe | Hulio® | 5% | 2021-04-07 |
| 02502402 | adalimumab 40 mg/0.8 mL pre-filled pen | Hulio® | 5% | 2021-04-07 |
| 02258595 | adalimumab 40 mg/0.8 mL kit | Humira® | 5% | 2011-04-01 |
| 02458349 02458357 |
adalimumab 40 mg/0.4 mL pre-filled syringe adalimumab 40 mg/0.4 mL pre-filled pen |
Humira® | 5% | 2017-04-01 |
| 02542315 02542331 02542323 |
adalimumab 20 mg/0.2 mL pre-filled syringe adalimumab 40 mg/0.4 mL autoinjector adalimumab 40 mg/0.4 mL pre-filled syringe |
Hyrimoz® | 5% | 2024-07-03 |
| 02492156 02492164 |
adalimumab 40 mg/0.8 mL autoinjector adalimumab 40 mg/0.8 mL pre-filled syringe |
Hyrimoz® | 5% | 2021-04-07 |
| 02542366 02542358 |
adalimumab 80 mg/0.8 mL autoinjector adalimumab 80 mg/0.8 mL pre-filled syringe |
Hyrimoz® | 5% | 2024-07-03 |
| 02502674 | adalimumab 40 mg/0.8 mL pre-filled pen | Idacio® | 5% | 2021-04-07 |
| 02502682 | adalimumab 40 mg/0.8 mL pre-filled syringe | Idacio® | 5% | 2021-10-01 |
| 02523949* 02523957* 02523965* |
adalimumab 40 mg/0.4 mL pre-filled syringe adalimumab 40 mg/0.4 mL autoinjector adalimumab 80 mg/0.8 mL pre-filled syringe (100 mg/mL high-dose formulation) |
Simlandi™ | 5% | 2022-08-18 |
| 02523779* 02523760* |
adalimumab 40 mg/0.4 mL pre-filled syringe adalimumab 40 mg/0.4 mL pre-filled pen (100 mg/mL high-dose formulation) |
Yuflyma® | 5% | 2022-08-18 |
| 02535084 02535076 |
adalimumab 80 mg/0.8 mL autoinjector adalimumab 80 mg/0.8 mL pre-filled syringe |
Yuflyma® | 5% | 2023-12-19 |
| 02418320 | alemtuzumab 10 mg/mL (1.2 mL) concentrated solution for IV infusion | Lemtrada® | 5% | 2018-04-12 |
| 02204606 | alpha 1-proteinase inhibitor 1000 mg vial | Prolastin-C® | 5% | 2011-04-01 |
| 02307065 02307073 |
ambrisentan 5 mg tablet ambrisentan 10 mg tablet |
Volibris® | 5% | 2012-04-02 |
| 02503034 | amifampridine 10 mg | Ruzurgi® | 5% | 2023-05-10 |
| 02502984 | amifampridine phosphate 10 mg tablet | Firdapse™ | 5% | 2025-02-05 |
| 02245913 | anakinra 100 mg/0.67 mL pre-filled syringe | Kineret® | 5% | 2011-04-01 |
| 02522845 | anifrolumab 300 mg/2 mL vial | Saphnelo® | 5% | 2025-06-04 |
| 02329840 | aztreonam 75 mg/vial powder for solution | Cayston™ | 5% | 2012-09-13 |
| 02131064 | baclofen 2 mg/mL ampule | Lioresal® | 5% | 2011-04-01 |
| 02526115 | belumosudil 200 mg tablet | Rezurock® | 1% | 2025-12-17 |
| 02473232 | benralizumab 30 mg/mL pre-filled syringe | Fasenra® | 5% | 2020-04-01 |
| 02496135 | benralizumab 30 mg/mL autoinjector pen | Fasenra® | 5% | 2021-04-28 |
| 02525267 02525275 |
bimekizumab 160 mg/mL pre-filled syringe bimekizumab 160 mg/mL autoinjector |
Bimzelx® | 5% | 2023-01-31 |
| 02553619 02553627 |
bimekizumab 320 mg/2 mL pre-filled syringe bimekizumab 320 mg/2 mL autoinjector |
Bimzelx® | 5% | 2025-07-16 |
| 02244981 02244982 |
bosentan 62.5 mg tablet bosentan 125 mg tablet |
Tracleer® | 5% | 2011-04-01 |
| 02531577 01981501 02531585 |
botulinum toxin 50 unit vial botulinum toxin 100 unit vial botulinum toxin 200 unit vial |
Botox® | 5% | 2011-04-01 |
| 02324032 | botulinum toxin 100 unit vial | Xeomin® | 5% | 2011-04-01 |
| 02543079 | cannabidiol 100 mg/mL oral solution | Epidiolex® | 5% | 2025-12-03 |
| 02266121 | cannabidiol/tetrahydrocannabinol 2.5 mg/2.7 mg per mL spray | Sativex® | 5% | 2012-04-02 |
| 02465574 | certolizumab pegol 200 mg/mL autoinjector or pre-filled pen | Cimzia® | 5% | 2018-02-01 |
| 02331675 | certolizumab pegol 400 mg/2 mL syringe kit | Cimzia® | 5% | 2011-04-01 |
| 02470179 | cladribine 10 mg tablet | Mavenclad® | 5% | 2026-01-02 |
| 02244849 | colistimethate sodium 150 mg vial | Colistimethate® | 5% | 2011-04-01 |
| 00476420 | colistimethate sodium 150 mg vial | Coly-Mycin® | 5% | 2015-04-01 |
| 02485605 | cysteamine ophthalmic solution 0.37% | Cystadrops® | 0% | 2022-02-28 |
| 02452219 02452227 02452235 |
deferasirox 90 mg tablet deferasirox 180 mg tablet deferasirox 360 mg tablet |
Jadenu® | 5% | 2017-10-26 |
| 02287447 | deferasirox 500 mg tablet for suspension | Exjade® | 5% | 2011-04-01 |
| 02436558 02436523 |
deferiprone 1000 mg tablet deferiprone 100 mg/mL oral solution |
Ferriprox® | 5% | 2017-01-18 |
| 02404508 02420201 |
dimethyl fumarate 120 mg capsule dimethyl fumarate 240 mg capsule |
Tecfidera® | 5% | 2014-12-15 |
| 02492504 02524252 02470365 02510049 |
dupilumab 200mg/1.14 mL pre-filled syringe dupilumab 200mg/1.14 mL pre-filled pen dupilumab 300mg/2 mL pre-filled syringe dupilumab 300mg/2 mL pre-filled pen |
Dupixent® | 5% | 2023-11-23 |
| 02475472 | edaravone 30 mg/100 mL solution for IV use | Radicava® | 0% | 2020-08-19 |
| 02532611 | edaravone oral suspension 105 mg/5 mL | Radicava ORS® | 0% | 2023-08-18 |
|
02517140 02526670 |
elexacaftor 100mg/tezacaftor 50mg/ivacaftor 75mg and ivacaftor 150mg oral tablets elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5mg and ivacaftor 75mg oral tablets |
Trikafta® | 0% | 2021-10-05 |
|
02542277 02542285 |
elexacaftor 100mg/tezacaftor 50mg/ivacaftor 75mg and ivacaftor 75mg oral granules elexacaftor 80mg/tezacaftor 40mg/ivacaftor 60mg and ivacaftor 59.5mg oral granules |
Trikafta® | 0% | 2023-12-14 |
| 02506742 02506769 |
eltrombopag olamine 25 mg tablet eltrombopag olamine 50 mg tablet |
Apo-eltrombopag | 5% | 2024-12-05 |
| 02361825 02361833 |
eltrombopag olamine 25 mg tablet eltrombopag olamine 50 mg tablet |
Revolade® | 5% | 2024-12-05 |
| 02397447 02397455 |
epoprostenol sodium (arginine) 0.5 mg vial epoprostenol sodium (arginine) 1.5 mg vial |
Caripul | 5% | 2014-12-22 |
| 02230848 | epoprostenol sodium 1.5 mg vial | Flolan® | 5% | 2011-04-01 |
| 02242903 02274728 |
etanercept 25 mg kit etanercept 50 mg/mL syringe |
Enbrel® | 5% | 2011-04-01 |
| 01968017 | filgrastim 300 mcg/mL vial | Neupogen® | 5% | 2011-04-01 |
| 02365480 | fingolimod 0.5 mg capsule | Gilenya® | 5% | 2013-06-13 |
| 02537702 | foslevodopa-foscarbidopa | Vyalev™ | 5% | 2024-08-20 |
| 02245619 | glatiramer acetate 20 mg kit | Copaxone® | 5% | 2011-04-01 |
| 02467550 | glecaprevir-pibrentasvir 100mg-40 mg tablet | Maviret™ | 2% | 2019-03-21 |
| 02522470 | glecaprevir-pibrentasivir 50 mg-40 mg oral granules in sachet | Maviret™ | 2% | 2024-08-20 |
| 02453304 | glycerol phenylbutyrate 1.1 g/mL oral liquid | Ravicti™ | 5% | 2018-04-12 |
| 02324776 02324784 |
golimumab 50 mg/0.5 mL pre-filled syringe golimumab 50 mg/0.5 mL autoinjector |
Simponi® | 5% | 2011-04-01 |
| 02487314 02469758 02566877 02559153 02559145 |
guselkumab 100 mg/mL auto injector guselkumab 100 mg/mL pre-filled syringe guselkumab 100 mg/mL pre-filled pen guselkumab 10 mg/mL vial guselkumab 100 mg/mL pre-filled pen |
Tremfya® | 5% | 2026-05-27 |
| 02146118 | hydromorphone 20 mg/mL vial | Dilaudid-HP-Plus® | 5% | 2011-04-01 |
| 02145936 | hydromorphone 20 mg/mL vial | Hydromorphone HP 20® | 5% | 2012-04-02 |
| 02145863 | hydromorphone 50 mg/mL vial | Dilaudid-XP® | 5% | 2012-04-02 |
| 02146126 | hydromorphone 50 mg/mL vial | Hydromorphone HP 50® | 5% | 2011-04-01 |
| 02241751 | imiglucerase 400 unit vial | Cerezyme® | 5% | 2011-04-01 |
| 02371081 | incobotulinumtoxinA (also known as clostridium botulinum toxin Type A) 50 unit vial | Xeomin® | 5% | 2014-04-01 |
| 02496933 | infliximab 100 mg vial | Avsola™ | 5% | 2021-04-01 |
| 66128531 | infliximab 100 mg vial | Inflectra® | 5% | 2025-05-01 |
| 02523191 | infliximab 100 mg vial | Ixifi® | 5% | 2025-05-01 |
| 02419475 | infliximab 100 mg vial | Remdantry™ | 5% | 2025-05-01 |
| 02244016 | infliximab 100 mg vial | Remicade® | 5% | 2011-04-01 |
| 02470373 | infliximab 100 mg vial | Renflexis™ | 5% | 2018-11-03 |
| 02237770 | interferon beta-1a 30 mcg /mL kit | Avonex® | 5% | 2012-04-02 |
| 02269201 | interferon beta-1a 30 mcg /0.5 mL kit | Avonex® PS | 5% | 2011-04-01 |
| 02281708 | interferon beta-1a 8.8 mcg/0.2 mL - 22 mcg/0.5 mL syringe initiation pack | Rebif® | 5% | 2012-04-02 |
| 02237319 02237320 02318253 02318261 |
interferon beta-1a 22 mcg/0.5 mL syringe interferon beta-1a 44 mcg/0.5 mL syringe interferon beta-1a 66 mcg/1.5 mL cartridge interferon beta-1a 132 mcg/1.5 mL cartridge |
Rebif® | 5% | 2012-04-02 |
| 02169649 | interferon beta-1b 0.3 mg vial | Betaseron® | 5% | 2011-04-01 |
| 02337819 | interferon beta-1b 0.3 mg vial | Extavia® | 5% | 2011-04-01 |
| 02455102 02455110 |
ixekizumab 80 mg/mL autoinjector ixekizumab 80 mg/mL pre-filled syringe |
Taltz™ | 5% | 2018-03-06 |
| 02549123 02549131 |
lebrikizumab 250 mg/2 mL pre-filled pen lebrikizumab 250 mg/2 mL pre-filled syringe |
Ebglyss® | 5% | 2026-08-05 |
| 02432226 | ledipasvir/sofosbuvir 90 mg-400 mg tablet | Harvoni® | 2% | 2017-03-01 |
| 02469375 02469383 |
letermovir 240 mg tablet letermovir 480 mg tablet |
Prevymis™ | 5% | 2021-05-18 |
| 02559323 02559331 |
letermovir 240 mg tablet letermovir 480 mg tablet |
Lupin-letermovir | 5% | 2026-09-03 |
| 02292165 | levodopa/carbidopa intestinal gel 20 mg/mL – 5 mg/mL | Duodopa® | 5% | 2017-08-24 |
| 02505541 02505568 |
luspatercept 25 mg vial luspatercept 75 mg vial |
Reblozyl® | 5% | 2023-03-14 |
| 02415690 | macitentan 10 mg tablet | Opsumit® | 5% | 2024-12-05 |
| 02530740 | maribavir 200 mg tablet | Livtencity™ | 5% | 2025-04-03 |
| 02532549 02532557 02532565 02532573 |
mavacamten 2.5 mg capsule mavacamten 5 mg capsule mavacamten 10 mg capsule mavacamten 15 mg capsule |
Camzyos™ | 5% | 2024-11-26 |
|
02492989 02492997 |
mepolizumab 100 mg/mL pre-filled autoinjector mepolizumab 100 mg/mL pre-filled safety syringe |
Nucala | 5% | 2020-05-26 |
| 02449781 | mepolizumab 100 mg/mL vial of lyophilized powder for subcutaneous injection | Nucala | 5% | 2018-11-13 |
| 02539845 02539853 |
mirikizumab 100 mg/mL pre-filled pen mirikizumab 100 mg/mL pre-filled syringe |
Omvoh® | 5% | 2024-11-19 |
|
02559242 02559234 |
mirikizumab 100 mg/mL one carton containing 2 pre-filled pens (100 mg/mL & 200 mg/2 mL) mirikizumab 100 mg/mL one carton containing 2 pre-filled syringes (100 mg/mL & 200 mg/2 mL) |
Omvoh® | 5% | 2026-05-27 |
| 02539861 | mirikizumab 300 mg/15 mL vial | Omvoh® | 5% | 2025-11-19 |
| 02286386 | natalizumab 300 mg/15 mL vial | Tysabri® | 5% | 2012-04-02 |
| 02325926 | nimodipine 30 mg tablet | Nimotop® | 5% | 2012-04-02 |
| 02443066 02443074 |
nintedanib 100 mg tablet nintedanib 150 mg tablet |
Ofev™ | 5% | 2018-04-12 |
| 02526905 | nintedanib 150 mg capsule | Auro-Nintedanib | 5% | 2026-06-04 |
| 02547538 | nintedanib 150 mg capsule | Eugia-Nintedanib | 5% | 2026-06-04 |
| 02540762 | nintedanib 150 mg capsule | Jamp-Nintedanib | 5% | 2026-06-04 |
| 02457717 02457725 02457733 02470055 |
nitisinone 2 mg capsule nitisinone 5 mg capsule nitisinone 10 mg capsule nitisinone 20 mg capsule |
MDK-Nitisinone | 5% | 2021-01-01 |
| 02459698 02459701 02459728 02459736 |
nitisinone 2 mg capsule nitisinone 5 mg capsule nitisinone 10 mg capsule nitisinone 20 mg capsule |
Orfadin® | 5% | 2021-01-01 |
| 02463121 02463148 |
obeticholic acid 5 mg tablet obeticholic acid 10 mg tablet |
Ocaliva | 5% | 2018-10-30 |
| 02467224 | ocrelizumab 30 mg/mL solution for IV use (10 mL vial) | Ocrevus® | 5% | 2020-08-10 |
| 00839205 | octreotide acetate 100 mcg/mL ampule | Sandostatin® | 5% | 2011-04-01 |
| 02561018 02561026 |
omalizumab 75 mg/0.5 mL pre-filled pen omalizumab 150 mg/mL pre-filled pen |
Omlyclo™ | 5% | 2026-07-15 |
| 02553805 02553813 |
omalizumab 75 mg/0.5 mL pre-filled syringe omalizumab 150 mg/1 mL pre-filled syringe |
Omlyclo™ | 5% | 2026-03-04 |
| 02459787 02459795 |
omalizumab 75 mg/mL pre-filled syringe omalizumab 150 mg/mL pre-filled syringe |
Xolair® | 5% | 2024-12-05 |
| 02260565 | omalizumab 150 mg vial | Xolair® | 5% | 2011-04-01 |
|
02505991 02506009 |
ozanimod hydrochloride 0.92 mg oral capsule ozanimod hydrochloride 0.23 mg and 0.46 mg oral capsules (7-day starter-pack) |
Zeposia® | 5% | 2024-01-16 |
| 02393751 02464500 02464489 |
pirfenidone 267 mg capsule pirfenidone 801 mg tablet pirfenidone 267 mg tablet |
Esbriet® | 5% | 2018-04-12 |
| 02542021 | posaconazole 100 mg tablet | Gln-Posaconazole | 5% | 2024-12-05 |
| 02424622 02293404 |
posaconazole 100 mg tablet posaconazole 200 mg/5 mL oral suspension |
Posanol® | 5% | 2024-12-05 |
| 02496259 | posaconazole 100 mg tablet | Sandoz® Posaconazole | 5% | 2024-12-05 |
| 02543311 | posaconazole 100 mg tablet | Taro-Posaconazole | 5% | 2024-12-05 |
| 02530333 | posaconazole 200 mg/5 mL oral suspension | Jamp-Posaconazole | 5% | 2024-12-05 |
| 02412764 02412772 02412799 02412802 02412810 |
riociguat 0.5 mg tablet riociguat 1 mg tablet riociguat 1.5 mg tablet riociguat 2 mg tablet riociguat 2.5 mg tablet |
Adempas® | 5% | 2024-12-05 |
| 02533545 02533561 02533588 02533596 02533618 |
riociguat 0.5 mg tablet riociguat 1 mg tablet riociguat 1.5 mg tablet riociguat 2 mg tablet riociguat 2.5mg tablet |
Sandoz® riociguat | 5% | 2025-05-01 |
| 02487454 | risankizumab 75 mg/0.83 mL pre-filled syringe | Skyrizi® | 5% | 2020-05-05 |
| 02519283 02519291 |
risankizumab 150 mg/mL pre-filled syringe risankizumab 150 mg/mL pre-filled pen |
Skyrizi® | 5% | 2022-10-18 |
|
02532107 02532093 |
risankizumab 600 mg/10 mL single-use vial risankizumab 360 mg/2.4 mL pre-filled cartridge with on-body injector |
Skyrizi® | 5% | 2024-05-30 |
| 02552507 | risankizumab 180 mg/1.2 mL pre-filled cartridge with on-body injector | Skyrizi® | 5% | 2026-05-27 |
| 02241927 | rituximab 10 mg/mL vial | Rituxan® | 5% | 2011-04-01 |
| 02322854 02322862 |
romiplostim 250 mcg/0.5 mL powder romiplostim 500 mcg/mL powder |
Nplate® | 5% | 2012-04-02 |
| 02556081 | rozanolixizumab 140 mg/mL 2mL single-dose vial | Rystiggo® | 0% | 2026-03-25 |
| 02388006 02434814 |
ruxolitinib 5 mg tablet ruxolitinib 10 mg tablet |
Jakavi® | 5% | 2023-11-28 |
| 02350580 02482207 02482215 |
sapropterin 100 mg tablet sapropterin 100 mg sachet sapropterin 500 mg sachet |
Kuvan® | 0% | 2022-09-27 |
| 02460521 02472961 02460548 02472988 |
sarilumab 150 mg/1.14 mL pre-filled syringe sarilumab 150 mg/1.14 mL pre-filled pen sarilumab 200 mg/1.14 mL pre-filled syringe sarilumab 200 mg/1.14 mL pre-filled pen |
Kevzara® | 5% | 2020-06-30 |
| 02499681 | satralizumab 120 mg/mL pre-filled syringe | Enspryng® | 0% | 2023-11-01 |
| 02547724 02438070 |
secukinumab 150 mg/mL pre-filled syringe secukinumab 150 mg/mL pre-filled pen |
Cosentyx® | 5% | 2016-11-10, updated 2025-01-28 |
| 02529653 02529661 |
secukinumab 300 mg/2 mL pre-filled syringe secukinumab 300 mg/2 mL pre-filled pen |
Cosentyx® | 5% | 2026-06-10 |
| 02451158 02451166 02451174 02451182 02451190 02451204 02451212 02451220 |
selexipag 200 mcg tablet selexipag 400 mcg tablet selexipag 600 mcg tablet selexipag 800 mcg tablet selexipag 1000 mcg tablet selexipag 1200 mcg tablet selexipag 1400 mcg tablet selexipag 1600 mcg tablet |
Uptravi® | 5% | 2018-10-30 |
| 02530139 02530147 |
selumetinib 10 mg capsule selumetinib 25 mg capsule |
Koselugo™ | 0% | 2025-02-12 |
| 02416441 | simeprevir sodium 150 mg capsule | Galexos™ | 2% | 2017-03-01 |
| 02496429 02496437 |
siponimod 0.25 mg oral tablet siponimod 2 mg oral tablet |
Mayzent® | 5% | 2026-01-02 |
| 66123781 | sodium phenyl butyrate powder Note: unclassed therapeutic non-benefits (SAP) |
Buphenyl® | 5% | 2011-04-01 |
| 02436663 | sodium phenylbutyrate 483 mg/g oral granules | Pheburane® | 5% | 2018-04-12 |
| 02418355 | sofosbuvir 400 mg tablet | Sovaldi® | 2% | 2017-03-01 |
| 02456370 | sofosbuvir-velpatasvir | Epclusa™ | 2% | 2017-03-21 |
| 02467542 | sofosbuvir-velpatasvir-voxilaprevir 400-100-100 mg tablet |
Vosevi™ | 2% | 2018-05-25 |
| 02243078 02243079 |
somatropin 12 mg cartridge somatropin 24 mg cartridge |
Humatrope® | 5% | 2011-04-01 |
| 02334852 02334860 02334879 |
somatropin 5 mg/1.5 mL pen somatropin 10 mg/1.5 mL pen somatropin 15 mg/1.5 mL pen |
Norditropin Nordiflex® | 5% | 2016-11-10 |
| 02529181 02529203 02529211 |
somatropin 5 mg/1.5 mL pen somatropin 10 mg/1.5 mL pen somatropin 15 mg/1.5mL pen |
Norditropin® Flexpro™ | 5% | 2023-07-04 |
| 02350149 | somatropin 20 mg/2 mL cartridge | Saizen® | 5% | 2012-04-02 |
| 02237971 | somatropin 5 mg vial | Saizen® | 5% | 2011-04-01 |
| 02551306 02551314 |
sotatercept 45 mg/vial (1-vial or 2-vial kit) sotatercept 60 mg/vial (1-vial or 2-vial kit) |
Winrevair® | 1% | 2026-03-11 |
| 02445727 | teduglutide 5 mg/vial | Revestive® | 0% | 2026-04-15 |
| 02416328 | teriflunomide 14 mg tablet | Aubagio® | 5% | 2015-03-02 |
|
02529548 02529556 |
tezepelumab 210 mg/1.91 mL pre-filled syringe tezepelumab 210 mg/1.91 mL autoinjector |
Tezspire™ | 5% | 2023-12-19 |
| 02365154 | tobramycin 28 mg capsule | Tobi® Podhaler® | 5% | 2012-09-13 |
| 02239630 | tobramycin sulphate 300 mg/5 mL solution for inhalation | Tobi® | 5% | 2012-09-13 |
| 02350092 | tocilizumab 80 mg/4 mL vial | Actemra® | 5% | 2011-08-09 |
| 02562022 02562065 02562057 |
tocilizumab 80 mg/4 mL vial tocilizumab 162 mg/0.9 mL autoinjector tocilizumab 162 mg/0.9 mL pre-filled syringe |
Avtozma™ | 5% | 2026-04-01 |
| 02552450 02552493 02552485 02552469 02552477 |
tocilizumab 80 mg/4 mL vial tocilizumab 162 mg/0.9 mL autoinjector tocilizumab 162 mg/0.9 mL pre-filled syringe tocilizumab 200 mg/10 mL vial tocilizumab 400 mg/20 mL vial |
Tyenne® | 5% | 2025-05-27 |
| 02483327* | tocilizumab 162 mg/0.9 mL autoinjector | Actemra® | 5% | 2022-08-11 |
| 02424770 | tocilizumab 162 mg/0.9 mL pre-filled syringe | Actemra® | 5% | 2016-07-01 |
| 02350106 02350114 |
tocilizumab 200 mg/10 mL vial tocilizumab 400 mg/20 mL vial |
Actemra® | 5% | 2011-08-09 |
| 02562030 02562049 |
tocilizumab 400 mg/10 mL vial tocilizumab 400 mg/20 mL vial |
Avtozma™ | 5% | 2026-04-01 |
| 02530015 | tofacitinib 10 mg tablet | Auro-tofacitinib | 5% | 2024-03-07 |
| 02511312 | tofacitinib 10 mg tablet | Taro-tofacitinib | 5% | 2024-03-07 |
| 02246552 02246554 02246555 |
treprostinil sodium 1 mg/mL vial treprostinil sodium 5 mg/mL vial treprostinil sodium 10 mg/mL vial |
Remodulin® | 5% | 2011-04-01 |
| 02246553 | treprostinil sodium 2.5 mg/mL vial | Remodulin® | 5% | 2012-04-02 |
| 02495155 02520893 |
upadacitinib 15 mg extended-release tablet upadacitinib 30 mg extended-release tablet |
Rinvoq® | 5% | 2023-11-28 |
| 02539721 | upadacitinib 45 mg extended-release tablet | Rinvoq® | 5% | 2024-09-17 |
| 02543036 02543044 |
ustekinumab 45 mg/0.5ml pre-filled syringe ustekinumab 90 mg/ml pre-filled syringe |
Jamteki™ | 5% | 2024-06-06 |
| 02554291 02554283 02554305 |
ustekinumab 90 mg/1.0 mL pre-filled syringe ustekinumab 45 mg/0.5 mL pre-filled syringe ustekinumab 130 mg/26 mL IV infusion |
Otulfi® | 5% | 2026-08-14 |
| 02550520 02550539 02550547 |
ustekinumab 130 mg/26 mL IV infusion ustekinumab 45 mg/0.5 mL pre-filled syringe ustekinumab 90 mg/1.0 mL pre-filled syringe |
Pyzchiva® | 5% | 2026-08-14 |
| 02320673 | ustekinumab 45 mg/0.5 mL vial | Stelara® | 5% | 2011-04-01 |
| 02320681 | ustekinumab 90 mg/1 mL vial | Stelara® | 5% | 2013-06-20 |
| 02550245 02550253 02550261 |
ustekinumab 45 mg/0.5 mL pre-filled syringe ustekinumab 90 mg/1.0 mL pre-filled syringe ustekinumab 130 mg/26 mL IV infusion |
Steqeyma® | 5% | 2024-09-17 |
| 02550253 02550261 |
ustekinumab 90 mg/1.0 mL pre-filled syringe ustekinumab 130 mg/26 mL IV infusion |
Steqeyma® | 5% | 2026-08-05 |
| 02544180 02544199 02544202 02544210 |
ustekinumab 45 mg/0.5 mL pre-filled syringe ustekinumab 90 mg/1.0 mL pre-filled syringe ustekinumab 45 mg/0.5 mL single use vial ustekinumab 130 mg/26 mL IV infusion |
Wezlana™ | 5% | 2024-10-01 |
| 02553309 02553317 |
ustekinumab 90 mg/1.0 mL pre-filled autoinjector ustekinumab 45 mg/0.5 mL pre-filled autoinjector |
Wezlana™ | 5% | 2026-08-14 |
| 02562103 02562111 02562081 |
ustekinumab 90 mg/1.0 mL pre-filled syringe ustekinumab 130 mg/26 mL IV infusion ustekinumab 45 mg/0.5 mL pre-filled syringe |
Yesintek™ | 5% | 2026-08-14 |
| 02497867 02497875 |
vedolizumab 108 mg/0.68 mL pre-filled pen vedolizumab 108 mg/0.68 mL pre-filled syringe |
Entyvio® | 5% | 2026-01-02 |
| 02436841 | vedolizumab 300 mg vial | Entyvio® | 5% | 2017-08-24 |
| 02549220 02549239 02549247 |
zilucoplan 16.6 mg/0.416 mL single-dose pre-filled syringe zilucoplan 23 mg/0.574 mL single-dose pre-filled syringe zilucoplan 32.4 mg/0.81 mL single-dose pre-filled syringe |
Zilbrysq® | 0% | 2026-03-25 |
Deletions
| DIN/PIN | Chemical description | Product name | Effective date of deletion |
|---|---|---|---|
| 02505258 | adalimumab 20 mg/0.4 mL | Hyrimoz® | 2026-02-02 |
| 02452294 | asunapravir | Sunpreva™ | 2018-01-13 |
| 02370816 | boceprevir 200 mg capsule | Victrelis™ | 2016-04-06 |
|
02371448 02371456 02371464 02371472 |
boceprevir/ribavirin/Peg-IFN-alfa-2b 200 mg/200 mg/80 mcg pen injection kit boceprevir/ribavirin/Peg-IFN-alfa-2b 200 mg/200 mg/100 mcg pen injection kit 200 mg/200 mg/120 mcg pen injection kit boceprevir/ribavirin/Peg-IFN-alfa-2b 200 mg/200 mg/150 mcg pen injection kit boceprevir/ribavirin/Peg-IFN-alfa-2b |
Victrelis Triple™ | 2016-04-06 |
| 02386194 | bosentan 62.5 mg tablet | Co Bosentan | 2015-04-01 |
| 02444747 02444755 |
daclatasvir 30 mg tablet daclatasvir 60 mg tablet |
Daklinza™ | 2020-07-29 |
| 02451131 | elbasvir-grazoprevir | Zepatier™ | 2022-08-01 |
| 02455323 02455331 |
etanercept 50 mg/mL syringe etanercept 50 mg/mL pen injector |
Brenzys® | 2018-05-01 |
| 02230694 | imiglucerase 200 unit vial | Cerezyme® | 2020-06-30 |
|
02240694 02240695 |
interferon alfa-2b 30 million IU recombinant pen injection kit interferon alfa-2b 60 million IU recombinant pen injection kit |
Intron A® | 2020-06-30 |
| 02436027 | ombitasvir-paritaprevir-ritonavir and dasabuvir 12.5 mg/75 mg/50 mg and 250 mg tablet | HOLKIRA™ PAK | 2017-03-21 |
|
02253410 02253429 |
ribavirin/PegIFN-alpha-2a, 200 mg tablet and 180 mcg/mL combination pkg ribavirin/PegIFN-alpha-2a, 200 mg tablet/180 mcg/0.5 mL combination pkg |
Pegasys® RBV | 2020-06-30 |
|
02246026 02246027 02246028 02246029 02246030 02254581 02254603 02254638 02254646 |
ribavirin/PegIFN-alpha-2b 200 mg cap/50 mcg/0.5 mL combination pkg ribavirin/PegIFN-alpha-2b 200 mg cap/80 mcg/0.5 mL combination pkg ribavirin/PegIFN-alpha-2b 200 mg cap/100 mcg/0.5 mL combination pkg ribavirin/PegIFN-alpha-2b 200 mg cap/120 mcg/0.5 mL combination pkg ribavirin/PegIFN-alpha-2b 200 mg cap/150 mcg/0.5 mL combination pkg ribavirin/PegIFN-alpha-2b 200 mg cap/80 mcg/0.5 mL pen injection kit ribavirin/PegIFN-alpha-2b 200 mg cap/100 mcg/0.5 mL pen injection kit ribavirin/PegIFN-alpha-2b 200 mg cap/120 mcg/0.5 mL pen injection kit ribavirin/PegIFN-alpha-2b 200 mg cap/150 mcg /0.5 mL pen injection kit |
Pegetron® | 2020-06-30 |
| 02527707 | sodium phenylbutyrate 3 g/ursodoxicoltaurine 1 g sachet | Albrioza™ | 2024-07-19 |
| 02249002 02216191 |
somatropin 10 mg/2 mL cartridge somatropin, kit: 10 mg vial (powder) + 10 mL vial (liquid) |
Nutropin® | 2020-06-30 |
| 02229722 | somatropin 10 mg/2 mL vial | Nutropin® AQ | 2020-06-30 |
| 02399091 02399083 02376393 |
somatropin 5 mg/2 mL cartridge somatropin 20 mg/2 mL cartridge somatropin 10 mg/2 mL cartridge |
Nutropin® AQ Nuspin | 2026-02-02 |
| 02272083 | somatropin 8.8 mg vial | Saizen® | 2020-06-30 |