PAD Refills

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Osteoporosis medication table update

This is a 2022 update to the BC Provincial Academic Detailing (PAD) Service’s 2011 table “Bisphosphonate Medications for Osteoporosis,” which includes all medications for osteoporosis that are approved in Canada. For complete details on PharmaCare coverage of medications for osteoporosis in British Columbia, please see the PharmaCare Special Authority web page.

Osteoporosis Medications Currently Available in Canada1
Generic Name, Brand Name, Available Strengths Health Canada Osteoporosis Indications Dosage and Annual Cost PharmaCare Coverage
BISPHOSPHONATES
alendronate
FOSAMAX, generics
5, 10, 70 mg tabs

alendronate + vitamin D3
FOSAVANCE
70 mg/2800, 70 mg/5600 IU tabs
  • Postmenopausal women
  • Men
  • Glucocorticoid induced osteoporosis
5 mg PO once a day $410 Non-benefit
10 mg PO once a day $160 Limited Coverage
70 mg PO once a week $120
70 mg/5600 IU PO once a week $115
70 mg/2800 IU PO once a week $210 Non-benefit
risedronate
ACTONEL, ACTONEL DR, generics
5, 35, 150 mg tabs
35 mg delayed-release (DR) tabs
  • Postmenopausal women
  • Men
  • Glucocorticoid induced osteoporosis
5 mg PO once a day $695 Limited Coverage
35 mg PO once a week $110
35 mg DR PO once a week $565 Non-benefit
150 mg PO once a month $530
zoledronic acid
ACLASTA, generics
5 mg/100 mL vial
  • Postmenopausal women
  • Men
  • Glucocorticoid induced osteoporosis
5 mg IV infusion once a year $360 Limited Coverage
DENOSUMAB rank ligand inhibitor
denosumab
PROLIA
60 mg single prefilled syringe
  • Postmenopausal women
  • Men
  • Glucocorticoid induced osteoporosis  
  • Nonmetastatic breast cancer receiving adjuvant aromatase inhibitor therapy
  • Nonmetastatic prostate cancer receiving androgen deprivation therapy
60 mg subcut every 6 months $860 Limited Coverage
RALOXIFENE selective estrogen receptor modulator
raloxifene
EVISTA, generics
60 mg tabs
  • Postmenopausal women
60 mg PO once a day $405 Limited Coverage
ROMOSOZUMAB sclerostin inhibitor
romosozumab
EVENITY
105 mg single prefilled syringe
  • Postmenopausal women
210 mg subcut once a month
maximum treatment: 12 months
$8510 Non-benefit
TERIPARATIDE synthetic parathyroid hormone
teriparatide
FORTEO, generics
OSNUVO biosimilar
250 mcg/mL multidose prefilled pen or cartridge
  • Postmenopausal women
  • Men
  • Glucocorticoid induced osteoporosis
20 mcg subcut once a day
maximum treatment: 24 months
$7960 Non-benefit
tabs tablets; PO by mouth; IU international units; IV intravenous; subcut subcutaneous;
†Cost without mark-up, professional fee or administration; calculated from McKesson Canada (accessed April 7, 2022)

1 Health Canada Drug Product Database


2022

2021

2020