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Last updated on June 4, 2025

June 2025 

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Split, open, sprinkle: navigating ADHD medication formulations

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Conclusion: Several ADHD medication formulations can be split or opened when tablets or capsules cannot be swallowed whole. The table below identifies which products can be modified in this way. Formulations which cannot be modified are excluded from the table and include: methylphenidate sustained release tablets (generics of Ritalin SR®), methylphenidate extended release (Concerta®), atomoxetine (generics of Strattera®) and guanfacine extended release (Intuniv XR® and generics). One product is available in a chewable formulation (Vyvanse® chewable tablets, generics).

The BC Provincial Academic Detailing (PAD) service’s archived topic, Medications for ADHD, compares different methylphenidate and amphetamine formulations, including an ADHD medications drug table with information on dose response and administration recommendations.1

Table: Modifiable and alternative formulations of medications for ADHD

Brand Name2 Dosage form2 Comments2 Wholesale cost for 30 days3 BC coverage4
Methylphenidate formulations
Ritalin® IR tablets
  • 10 mg and 20 mg scored tablets (some generic 5 mg brands are unscored)
  • name brand no longer available
generic: $10-$35
brand: none
Regular benefit
Biphentin® CR capsules
  • sprinkle onto 15 mL of applesauce, ice cream, yogurt
  • consume within 30 minutes
  • do not sprinkle in liquids, crush or chew
generic: $25-$140
brand: $30-$200
Non benefit
Foquest® CR capsules
  • sprinkle onto 15 mL of applesauce, ice cream, yogurt
  • consume within 10 minutes
  • do not sprinkle in liquids, crush or chew
generic: none
brand: $95-$165 
Non benefit
Quillivant ER® chewable tablets
oral supension 
  • 10 mg or 15 mg dose can be achieved by halving the scored 20 mg or 30 mg tablets (40 mg is not scored)
  • suspension supplied as 300mg/60ml, 600mg/120ml, 750mg/150ml and 900mg/180ml (5mg/ml when reconstituted)  
  • suspension and chew tabs are not interchangeable
generic: none
brand tabs: $90-$195 
brand susp: $80-$200 
Non benefit
Amphetamine formulations 
Dexedrine®  IR tablets
  • 5 mg tablets are scored 
generic: $10-$135
brand: $15-$215 
Regular benefit
Dexedrine Spansule® SR capsules
  • capsule contains pellets: should not be crushed/chewed 
  • opening not expected to compromise SR properties if pellets ingested whole and immediately after opening
generic: $30-$115
brand: $40-$160
Regular benefit
Adderall XR®  ER capsules
  • sprinkle onto applesauce; consume immediately
  • do not crush or chew
generic: $20-$30  
brand: $80-$135
Limited coverage
Vyvanse® capsules
  • mix with yogurt, water or orange juice
  • consume immediately
generic: $20-$45
brand: $75-$185
Limited coverage
IR: immediate release; ER/XR: extended release; SR: sustained release; DR: delayed release
Table does not include products that are recommended to only swallow whole (not cut, crush, chew, or open)

1BC PAD Service Medications for ADHD: Focus on drug information (January 2024 update); 2Health Canada Drug Product Database; 3McKesson.ca; 4BC PharmaCare Formulary; 5Paladin Labs Inc. medical information request, Ref: PAL-12052022-2444 response May 18, 2022.

Please visit www.bcpad.ca to book a session with the academic detailing pharmacist in your area

 

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