Effective Date: April 1, 2011
Revised Date: April 1, 2013
Table 1: Clinical Triggers / Red Flags
Screening - Asking About Alcohol Use
Assessment For Alcohol Abuse or Dependence
Questions and Criteria for Assessing Abuse
This guideline provides practitioners with practical information on how to conduct screening for problem drinking in adults aged ≥ 19 years.* Approximately 350,000 British Columbians are problem drinkers.1 This means that in a typical family practice of 1,500 patients, 120-200 patients are at risk for alcohol abuse or dependence. Problem drinking affects the medical management of every chronic medical and mental health condition. Research has shown that many screened patients cut down on their drinking simply because they were asked about their alcohol use, and effective screening for problem drinking can be completed in as little as 5 minutes.2 Although this document does not deal specifically with teenagers, screening for this age group is also recommended.
* Significant portions of this guideline were adapted from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), "Helping Patients Who Drink Too Much", A Clinicians' Guide, Updated 2005 Edition, and should be fully acknowledged for developing this useful clinical tool. A full copy of their guideline and reference materials can be found on NIAAA's website at http://pubs.niaaa.nih.gov
The following steps are outlined in this guideline:
Diagnostic Code: | 303: Alcohol dependence syndrome 305: Non dependent use of drugs |
Screening identifies patients who need further assessment or treatment by determining their level of risk based on reported alcohol use and other relevant clinical information. Consider the following two screening questions during any patient interaction, when clinical triggers/red flags are observed (see Table 1) and/or when a patient fails to respond to appropriate management (see Screening - Asking About Alcohol Use [PDF, 154KB]).
Q1. | Do you sometimes drink beer, wine or other alcoholic beverages? |
Q2. | How many times in the past year have you had - 5 or more drinks in one day (men)? 4 or more drinks in one day (women)? |
Practitioners may wish to use the Alcohol Screening Note (PDF, 154KB) provided with this guideline.
Interventions should be selected based on the assessment completed during the screening. Although alcohol misuse is a spectrum disorder, positive screens will fall into one of three categories:
1. At-risk drinking: | Men - 5 or more drinks on one or more days in the last year. Women - 4 or more drinks on one or more days in the last year. |
2. Alcohol abuse: | Patient meets 1 or more Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria for abuse in the last 12 months. |
3. Alcohol dependence: | Patient meets 3 or more DSM IV criteria for dependence in the last 12 months. |
Medical | Mental | Psychosocial |
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Note: Laboratory evaluation, including liver function tests, are not necessary unless clinically indicated and are not sensitive enough to be used alone as screening tests.
Abbreviations: MCV, Mean cell volume; GGT, Gamma-glutamyl transpeptidase; AST, Aspartate aminotransferase; ALT, Alanine transaminase; GERD, Gastroesophageal reflux disease; DUI, Driving under the influence; STI, Sexually transmitted infection
Assessment
General questions
One of the following introductory questions can be used before asking about abuse or dependence:
Q. Has your life ever been affected by alcohol?
Q. Has your spouse or anyone said anything about your drinking?
Q. How long have you been drinking like this?
In the past 12 months, has the patient's drinking caused or contributed to - | Sample Questions | No | Yes |
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A1. Role failure | Q. Have you missed work or class because of your drinking? | ||
A2. Risk of bodily harm | Q. Do you sometimes drink and drive? | ||
A3. Run-ins with the law / legal issues | Q. Have you been charged with a DUI or been given a road side suspension? | ||
A4. Relationship trouble | Q. Has your spouse or family complained about your drinking? |
Conclusion - | Yes ≥ 1 --- your patient has alcohol abuse. Proceed to the questions below. No --- proceed to Part 2 - Brief Intervention for At-Risk Drinking. |
In the past 12 months, the patient has - | Sample Questions | No | Yes |
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D1. Increased tolerance | Q. Do you need to drink more to get the same affect? | ||
D2. Experienced withdrawal | Q. When you stop drinking, have you ever experienced physical or emotional withdrawal? Have you had any of the following symptoms: irritability, anxiety, shakes, sweats, nausea, or vomiting? | ||
D3. Failed to stick to drinking limits | Q. Do you often drink more than you plan to? | ||
D4. Failed attempts to cut down or stop drinking | Q. Have you ever tried to cut down or stop drinking? How long did that last? | ||
D5. Spent a lot of time on drinking related activities | Q. Do you spend more time thinking about or recovering from alcohol than you used to? Have you ever thought of ways to avoid getting caught? | ||
D6. Spent less time on other matters | Q. Have you reduced family or recreational events because of alcohol use in the past year? | ||
D7. Kept drinking despite psychological or physicalproblems | Q. Do you think that drinking is causing problems for you? What keeps you drinking? |
Conclusion - | Yes ≥ 3 --- your patient has alcohol dependence. Proceed to Part 2 - Brief Intervention for Alcohol Dependence. No --- your patient still has alcohol abuse. Proceed to Part 2 - Brief Intervention for Alcohol Abuse. |
Every health care practitioner will encounter patients with alcohol problems in their practice. It is therefore important that all adolescent and adult patients be screened for problem drinking at some time. In BC as many as one in 10 visits to Vancouver General Hospital Emergency Room was for substance abuse.4 As well, the number of patients staying at Vancouver General and University of British Columbia Hospitals due to substance abuse increased by 44% between 2005 and 2008 (from 1,317 to 1,896).5 Screening and brief intervention are effective ways to reduce alcohol use as well as reduce acute care utilization. Research shows:
Research has also shown that many screened patients cut down on their drinking simply because they were asked about their alcohol use; likewise, brief interventions have been shown to effectively reduce alcohol and other drug use.9
BC Health Authority Websites - search under mental health and substance use | |
Fraser Health Authority: | www.fraserhealth.ca |
Interior Health Authority: | www.interiorhealth.ca |
Northern Health Authority: | www.northernhealth.ca |
Provincial Health Services Authority: | www.phsa.ca |
Vancouver Coastal Health Authority: | vch.eduhealth.ca www.vch.ca |
Vancouver Island Health Authority: | www.viha.ca |
British Columbia Resources
Centre for Addictions Research of BC: www.carbc.ca
Centre for Applied Research in Mental Health and Addiction: www.carmha.ca.
Canadian Centre on Substance Abuse: www.ccsa.ca
Centre for Addiction and Mental Health: www.camh.net
Clinical Institute Withdrawal Assessment of Alcohol Scale, Revised (CIWA-Ar): www.chce.research.va.gov
CRAFFT: www.projectcork.org
Here to Help: www.heretohelp.ca
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
For examples on conducting screening and interventions, please visit:
https://www.niaaa.nih.gov/health-professionals-communities/core-resource-on-alcohol/screen-and-assess-use-quick-effective-methods
Physicians are strongly recommended to complete the NIAAA case examples (and CME credits) as it will assist them in using the guideline.
Materials on the website also include:
Appendix A - Standard Drink Size Illustration (PDF, 195KB)
Alcohol Screening Note (HLTH 2824) (PDF, 154KB)
Brief Intervention For At-Risk Drinking (no abuse or dependence)
Intervention for Alcohol Abuse
This guideline provides practitioners with practical information on how to conduct brief intervention for problem drinking in adults aged ≥ 19 years and can be used after a positive screen occurs when using the BC Guideline "Screening for Problem Drinking".* Once screening is complete and a patient is deemed at-risk, physicians may perform a brief intervention. Problem drinking is a behaviour that can be changed through intervention, and physicians in primary and hospital based care are in a key position to make a difference.1-5 A study of two minute brief intervention screenings concluded that "self reported patient status at 6 months indicated significant improvements over baseline for illicit drug use and heavy alcohol use."6
Brief interventions motivate patients to lower their risk for alcohol related problems and are often successful in addressing other medical issues including medication adherence, weight loss, smoking cessation and dietary habits. If your patient is seeing you for another problem, it may be necessary for screening to be done at the first appointment and intervention done at a follow up appointment.
* Significant portions of this guideline were adapted from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), "Helping Patients Who Drink Too Much", A Clinicians' Guide, Updated 2005 Edition, and should be fully acknowledged for developing this useful clinical tool. A full copy of their guideline and reference materials can be found on NIAAA's website at http://pubs.niaaa.nih.gov
The following steps are outlined in this guideline:
Diagnostic Code: | 303: Alcohol dependence syndrome 305: Non dependent use of drugs |
Selected interventions should be based on the assessment completed during the screening (See Problem Drinking Part 1 - Screening and Assessment). Although alcohol misuse is a spectrum disorder, positive screens will fall into one of three categories.
1. At-risk drinking: | Men - 5 or more drinks on one or more days in the last year. Women - 4 or more drinks on one or more days in the last year. |
2. Alcohol abuse: | Patient meets 1 or more Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria for abuse in the last 12 months. |
3. Alcohol dependence: | Patient meets 3 or more DSM IV criteria for dependence in the last 12 months. |
Practitioners may wish to use the Brief Intervention Follow-up Note (PDF, 147KB) provided with this guideline.
Every health care practitioner will encounter patients with alcohol problems in their practice. It is therefore important that all adolescent and adult patients be screened for problem drinking at some time. In BC as many as one in 10 visits to Vancouver General Hospital Emergency Room was for substance abuse.7 As well, the number of patients staying at Vancouver General and University of British Columbia Hospitals due to substance abuse increased by 44% between 2005 and 2008 (from 1,317 to 1,896).8 Screening and brief intervention are effective ways to reduce alcohol use as well as reduce acute care utilization. Research shows:
Research has also shown that many screened patients cut down on their drinking simply because they were asked about their alcohol use; likewise, brief interventions have been shown to effectively reduce alcohol and other drug use.13
Brief Intervention Follow-up Note (HLTH 2825) (PDF, 147KB)
Section 1 - Office Based Management of Alcohol Withdrawal
Table 1: Treating Alcohol Withdrawal With Diazepam (Valium)
This guideline provides practitioners with practical information on how to conduct office based management of withdrawal and medication management for adults aged ≥ 19 years with alcohol dependence.
* Significant portions of this guideline were adapted from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), "Helping Patients Who Drink Too Much", A Clinicians' Guide, Updated 2005 Edition, and should be fully acknowledged for developing this useful clinical tool. A full copy of their guideline and reference materials can be found on NIAAA's website at http://pubs.niaaa.nih.gov
The following are outlined in this guideline:
Diagnostic Code: | 303: Alcohol dependence syndrome 305: Non dependent use of drugs |
Family physicians with a supportive, nonjudgmental, yet assertive attitude can be a great asset in confronting and treating patients with alcohol and other substance abuse problems. With the right attitude and the right tools, primary care physicians can manage most patients through the withdrawal phase of their illness and be a powerful influence in their ongoing struggle for recovery.1
Contraindications to outpatient alcohol withdrawal management:
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Benzodiazepines are considered the treatment of choice for the management of alcohol withdrawal symptoms. Benzodiazepines reduce the signs and symptoms of alcohol withdrawal, incidence of delirium, and seizures. Based on indirect comparisons there is currently no strong evidence that particular benzodiazepines are more effective than others and selection should be made on an individual basis.2,3 Alprazolam and triazolam are not recommended.
Diazepam (Valium®) is recommended because of its efficacy profile, wide therapeutic window and "self tapering" effect due to its long half life. Other benzodiazepines can be considered such as: clonazepam, lorazepam and oxazepam. In the case of intolerance to benzodiazepines, physicians may wish to consider using a different class of medications (e.g., anticonvulsants). It is recommended that physicians with less experience with diazepam follow the rigid schedule. Physicians with experience using diazepam for alcohol withdrawal can consider front loading. Three medication protocols are provided (see Table 1).
When conducting outpatient withdrawal, do the following:
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Schedule | Day 1 | Day 2 | Day 3 | Day 4 |
Rigid | 10 mg four times daily | 10 mg three times daily | 10 mg twice daily | 10 mg at bedtime |
Flexible | 10 mg every 4 to 6 hours as needed based on symptoms* | 10 mg every 6 to 8 hours as needed | 10 mg every 12 hours as needed | 10 mg at bedtime as needed |
Front loading** | 20 mg every 2 to 4 hours until sedation is achieved; then 10 mg every 4 to 6 hours as needed. Max 60 mg/day | 10 mg every 4 to 6 hours as needed. Max 40 mg/day | 10 mg every 4 to 6 hours as needed. Max 40 mg/day | None |
* Pulse rate >100 per minute, diastolic BP > 90 mm Hg or signs of withdrawal.
** Frequently, very little additional medication is necessary after initial loading.
Note: Benzodiazepines should be discontinued after withdrawal symptoms resolved (5-7 days).
Three medications are currently available: Naltrexone: Blocks euphoria associated with alcohol use. CONTRAINDICATED in patients taking opiates. |
Why should medications be considered for treating an alcohol use disorder?
Consider pharmacotherapy for all patients with alcohol dependency. Patients who fail to respond to psychosocial approaches and/or addiction counselling are particularly strong candidates. The above medications can be used immediately following withdrawal or any time thereafter; however, these medications should be used in conjunction with addiction counselling and other psychosocial supports.
Must patients agree to abstain?
No matter which alcohol dependence medication is used, patients who have a goal of abstinence, or who can abstain even for a few days prior to starting the medication, are likely to have better outcomes. Still, it is best to determine individual goals with each patient. Some patients may not be willing to endorse abstinence as a goal, especially at first. However, abstinence remains the optimal outcome.
A patient's willingness to abstain has important implications for the choice of medication. For example, a study of oral naltrexone demonstrated a modest reduction in the risk of heavy drinking in people with mild dependence who chose to cut down rather than abstain.4 Acamprosate is approved for use in patients who are abstinent at the start of treatment. Total abstinence is needed with disulfiram. Disulfiram is contraindicated in patients who continue to drink, because a disulfiram-alcohol reaction occurs with any alcohol intake.
Which of the medications should be prescribed? (see Appendix A: Prescription Medication Table for Alcohol Dependence (PDF, 142KB))
Which medication to use will depend on clinical judgment and patient preference. Each has a different mechanism of action. Some patients may respond better to one type of medication than another.
NALTREXONE:
Naltrexone works by blocking the euphoria associated with alcohol use. Its use is CONTRAINDICATED in patients taking opiates. Oral naltrexone is associated with lower percentage drinking days, fewer drinks per drinking day, and longer times to relapse.5,6 It is most effective in patients with strong cravings. Efficacy beyond 12 weeks has not been established. Although it is especially helpful for curbing consumption in patients who have drinking "slips" it may also be considered in patients who are motivated, have intense cravings and are not using or going to be using opioids. It appears to be less effective in maintenance of abstinence as meta-analyses have shown variable results. Monitoring of liver enzymes may be required.
ACAMPROSATE:
Acamprosate works by reducing chronic withdrawal symptoms. Acamprosate increases the proportion of dependent drinkers who maintain abstinence for several weeks to months, a result demonstrated in multiple European studies and confirmed by a meta-analysis of 17 clinical trials.7 However, this has not been demonstrated in patients who have NOT undergone detoxification and NOT achieved alcohol abstinence prior to beginning treatment. Acamprosate should be initiated as soon as possible after detoxification and the recommended duration of treatment is one year. There is currently insufficient evidence to suggest that acamprosate has a therapeutic advantage over naltrexone.
DISULFIRAM:
Disulfiram is an adversive agent that causes nausea, vomiting, and dysphoria with alcohol use. Abstinence and counselling are required before initiation of treatment with disulfiram. Data on the effectiveness of disulfiram in alcohol use disorders is mixed. Disulfiram has been shown to have modest effects on maintaining abstinence from alcohol, particularly if it is administered under supervision. It is most effective when given in a monitored fashion, such as in a clinic or by a spouse. Thus the utility and effectiveness of disulfiram may be considered limited because compliance is generally poor when patients are given it to take at their own discretion.8,9 Disulfiram may be considered for those patients that can achieve initial abstinence, are committed to maintaining abstinence, can understand the consequences of drinking alcohol while on disulfiram, and can receive adequate ongoing supervision. It may also be used episodically for high-risk situations, such as social occasions where alcohol is present. Daily uninterrupted disulfiram therapy should be continued until full patient recovery, which may require months to years.
How long should medications be maintained?
The risk for relapse to alcohol dependence is very high in the first 6 to 12 months after initiating abstinence and gradually diminishes over several years. Therefore, a minimum initial period of 6 months of pharmacotherapy is recommended. Although an optimal treatment duration has not been established, treatment can continue for one to two years if the patient responds to medication during this time when the risk of relapse is highest. After patients discontinue medications, they may need to be followed more closely and have pharmacotherapy reinstated if relapse occurs.
If one medication does not work, should another be prescribed?
If there is no response to the first medication selected, you may wish to consider a second. This sequential approach appears to be common clinical practice, but currently there are no published studies examining its effectiveness. There is not enough evidence to recommend a specific ordering of medications.
Is there any benefit to combining medications?
There is no evidence that combining any of the medications to treat alcohol dependence improves outcomes over using any one medication alone.
Should patients receiving medications also receive specialized alcohol counselling or a referral to mutual help groups?
Offering the full range of effective treatments will maximize patient choice and outcomes, since no single approach is universally successful or appealing to patients. Medications for alcohol dependence, professional counselling, and mutual support groups are part of a comprehensive approach. These approaches share the same goal while addressing different aspects of alcohol dependence: neurobiological, psychological, and social. The medications are not prone to abuse, so they do not pose a conflict with other support strategies that emphasize abstinence. Using medications to treat patients does not interfere with counselling or other abstinence based programs such as AA.
Almost all studies of medications for alcohol dependence have included some type of counselling, and it is recommended that all patients taking these medications receive at least brief medical counselling. In a recent large trial, the combination of oral naltrexone and brief medical counselling sessions delivered by a nurse or physician was effective without additional behavioral treatment by a specialist.10 Patients were also encouraged to attend mutual support groups to increase social encouragement for abstinence.
Outpatient alcohol withdrawal is safe and cost effective for the vast majority of problem drinkers.11-14 Only about 20 per cent of problem drinkers require a hospital based or inpatient setting for alcohol detoxification.1 Patients are treated earlier in the course of their disease in an office based setting which prevents further complications, and reduces the need for hospitalization. Withdrawal as an outpatient is more effective in reaching certain populations that may not use inpatient detox, such as women, children, youth, older adults, psychiatric populations, human immunodeficiency virus (HIV) affected, and people with other disabilities.
Appendix A: Prescription Medication Table for Alcohol Dependence (PDF, 195KB)
This guideline is based on scientific evidence as of the Effective Date.
This guideline was developed by the Guidelines and Protocols Advisory Committee, approved by the British Columbia Medical Association, and adopted by the Medical Services Commission.
The principles of the Guidelines and Protocols Advisory Committee are to:
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Disclaimer The Clinical Practice Guidelines (the "Guidelines") have been developed by the Guidelines and Protocols Advisory Committee on behalf of the Medical Services Commission. The Guidelines are intended to give an understanding of a clinical problem and outline one or more preferred approaches to the investigation and management of the problem. The Guidelines are not intended as a substitute for the advice or professional judgment of a health care professional, nor are they intended to be the only approach to the management of clinical problems. We cannot respond to patients or patient advocates requesting advice on issues related to medical conditions. If you need medical advice, please contact a health care professional.