Drug Decision Summaries & Evidence Reports

To provide British Columbians with more information on drugs that have been considered for coverage, PharmaCare makes the following documents available on this page: Drug Decision Summaries, Drug Benefit Council (DBC) Reasons and Recommendations, Clinical Evidence Reports, and Pharmacoeconomic Evidence Reports.

These documents may include information about:

  • the specific drug
  • the disease or condition the drug is used to treat
  • PharmaCare’s coverage decision
  • the reasons this drug is or is not being covered by PharmaCare
  • clinical evidence and/or cost-effectiveness

Note: Not all drugs that have been considered for coverage under PharmaCare have a Drug Decision Summary, DBC Reasons and Recommendations, Clinical Evidence Report, or Pharmacoeconomic Evidence Report. New documents are added regularly.

To view, click on the document link in the row of the specific drug.

Generic Name

Brand Name

Indication

PharmaCare Decision Date

Documents

abatacept (SQ)

Orencia®

Rheumatoid arthritis

25-Feb-2014

Drug Decision Summary
(PDF, 126KB)

aclidinium

Tudorza™ Genuair™

Chronic Obstructive Pulmonary Disease (COPD)

30-Sep-2014

Drug Decision Summary
(PDF, 329KB)

aclidinium bromide-formoterol fumarate dehydrate

Duaklir™ Genuair®

Chronic Obstructive Pulmonary Disease (COPD)

5-Apr-2016

Drug Decision Summary
(PDF, 328KB)

adalimumab

Humira®

difficult to treat Crohn’s disease

09-Sep-2008

Drug Decision Summary
(PDF, 109KB)

adalimumab

Humira®

Juvenile idiopathic arthritis

25-Feb-2014

Drug Decision Summary
(PDF, 126KB)

adalimumab 

Humira®

Hidradenitis Suppurativa (HS)

18-Apr-2017

Drug Decision Summary
(PDF, 323KB)

adefovir

Hepsera®

chronic hepatitis B

27-Mar-2008

Drug Decision Summary
(PDF, 190KB)

alogliptin

Nesina™ 

Type 2 Diabetes Mellitus (T2DM)

05-May-2015

Drug Decision Summary
(PDF, 323KB)

alogliptin-metformin

Kazano™

Type 2 Diabetes Mellitus (T2DM)

05-May-2015

Drug Decision Summary
(PDF, 361KB)

apixaban

Eliquis®

Stroke prophylaxis in atrial fibrillation

19-Sep-2013

Drug Decision Summary
(PDF, 108KB)

apixaban

Eliquis®

prevention of venous thromboembolic events

10-Dec-2013

Drug Decision Summary
(PDF, 110KB)

apixaban

Eliquis

Thromboembolic events (venous), treatment and prevention of recurrence

5-Apr-2016

Drug Decision Summary
(PDF, 325KB)

aprepitant

Emend®

for prevention of vomiting in patients with cancer

16-Mar-2010

Drug Decision Summary
(PDF, 427KB)

aripiprazole

Abilify®

major depressive disorder (MDD)

14-Apr-2015

Drug Decision Summary
(PDF, 361KB)

aripiprazole monohydrate

Abilify Maintena™

Schizophrenia

11-Aug-2015

Drug Decision Summary
(PDF, 361KB)

asunaprevir

Sunvepra™

Chronic Hepatitis C (CHC)

21-Mar-2017

Drug Decision Summary (PDF, 355KB)

Attention Deficit Hyperactivity Disorder (ADHD) therapeutic review

N/A

ADHD

18-Apr-2017

Drug Decision Summary (PDF, 332KB)

azelastine hydrochloride – fluticasone propionate

Dymista®

moderate to severe seasonal allergic rhinitis and associated ocular symptoms

29-Sep-2015

Drug Decision Summary
(PDF, 363KB)

azilsartan

Edarbi

Hypertension, essential

29-Jul-2014

Drug Decision Summary
(PDF, 329KB)

azilsartan

Edarbyclor

Hypertension, essential

29-Jul-2014

Drug Decision Summary
(PDF, 330KB)

boceprevir

Victrelis™

HIV/Hepatitis C

10-Oct-2013

Drug Decision Summary
(PDF, 109KB)

brinzolamide-brimonidine

Simbrinza®

Glaucoma and ocular hypertensio

27-Oct-2015

Drug Decision Summary
(PDF, 324KB)

buprenorphine-naloxone

Suboxone®

opioid drug dependence in adults

13-Oct-2015

Drug Decision Summary
(PDF, 365KB)

canakinumab

Ilaris®

active systemic Juvenile Idiopathic Arthritis (sJIA) in patients aged two years and older

10-Jan-2017

Drug Decision Summary
(PDF, 320KB)

certolizumab pegol

Cimzia®

Arthritis, psoriatic

19-Feb-2016

Drug Decision Summary
(PDF, 326KB)

certolizumab pegol

Cimzia®

Ankylosing spondylitis

19-Feb-2016

Drug Decision Summary
(PDF, 325KB)

ciprofloxacin + dexamethasone
(ear drops)

Ciprodex®

acute otitis media with otorrhea and otitis externa

18-Jul-2005

Drug Decision Summary
(PDF, 72KB)

clopidogrel (1)

Plavix®

after drug-eluting stent insertion

18-Feb-2008

Drug Decision Summary
(PDF, 68KB)

clopidogrel (2)

Plavix®

Acute Coronary Syndrome

16-Mar-2010

Drug Decision Summary
(PDF, 182KB)

clostridium botulinum neurotoxin type A, with complexing proteins

Xeomin®

muscle spasticity

15-Jun-2010

Drug Decision Summary
(PDF, 403KB)

colesevelam hydrochloride

Lodalis

Hypercholesterolemia

13-Jun-2013

Drug Decision Summary
(PDF, 109KB)

collagenase clostridium histolyticum

Xiaflex™

Dupuytren’s contracture with a palpable cord

25-Mar-2014

Drug Decision Summary
(PDF, 347KB)

daclatasvir

Daklinza™

Chronic Hepatitis C (CHC)

21-Mar-2017

Drug Decision Summary (PDF, 355KB)

deferiprone

Ferriprox™

Transfusional iron overload due to thalassemia syndromes

25-Oct-2016

Drug Decision Summary
(PDF, 324KB)

delta-9-tetrahydrocannabinol + cannabidiol (1)

Sativex®

adjunctive neuropathic pain relief in multiple sclerosis

23-Dec-2008

Drug Decision Summary
(PDF, 67KB)

delta-9-tetrahydrocannabinol + cannabidiol (2)

Sativex®

adjunctive pain relief in advanced cancer

23-Dec-2008

Drug Decision Summary
(PDF, 67KB)

denosumab

Prolia ®

for the Treatment of men with osteoporosis at high risk for fracture or who have failed or are intolerant to other available osteoporosis therapy

14-Feb-2017

Drug Decision Summary
(PDF, 320KB)

denosumab

Xgeva

Prevention of skeletal-related events due to bone metastases from solid tumours

17-Jan-2017

Drug Decision Summary
(PDF, 321KB)

dimethyl fumerate

Tecfidera™

Multiple Sclerosis, relapsing

24-Jun-2014

Drug Decision Summary
(PDF, 329KB)

doxycycline

Apprilon®

Rosacea

28-Jan-2014

Drug Decision Summary
(PDF, 124KB)

eculizumab

Soliris®

Hemolytic Uremic Syndrome, Atypical

14-Jan-2014

Drug Decision Summary
(PDF, 319KB)

elbasvir-grazoprevir

Zepatier®

Chronic Hepatitis C (CHC)

21-Mar-2017

Drug Decision Summary (PDF, 355KB)

elosulfase alfa

Vimizim™

mucopolysaccharidosis type IVA (MPS IVA or Morquio A syndrome)

22-Sep-2015

Drug Decision Summary
(PDF, 362KB)

eltrombopag

Revolade®

Chronic Hepatitis C Associated Thrombocytopenia (low platelet counts)

14-Jul-2015

Drug Decision Summary
(PDF, 361KB)

entecavir

Baraclude™

chronic hepatitis B in patients who develop cirrhosis

27-Mar-2008

Drug Decision Summary
(PDF, 133KB)

eplerenone

Inspra®

Heart failure, NYHA class II

18-Nov-2014

Drug Decision Summary
(PDF, 358KB)

eslicarbazepine acetate

Afinitor®

Epilepsy, partial-onset seizures

10-Nov-2015

Drug Decision Summary
(PDF, 326KB)

everolimus (1)

Afinitor®

renal angiomyolipoma associated with tuberous sclerosis complex (TSC)

12-Aug-2014

Drug Decision Summary
(PDF, 326KB)

everolimus (2)

Afinitor®

subependymal giant cell astrocytoma (SEGA), a brain tumour associated with a genetic condition called tuberous sclerosis complex (TSC)

28-Jul-2015

Drug Decision Summary
(PDF, 361KB)

exenatide

Byetta

Type 2 Diabetes Mellitus (T2DM)

20-Jun-2013

Drug Decision Summary
(PDF, 278KB)

ezetimibe (1)

Ezetrol®

hypercholesterolemia

08-Nov-2007

Drug Decision Summary
(PDF, 64KB)

ezetimibe (2)

Ezetrol®

high cholesterol in patients with specific variants of NPC1L1 protein

10-Sep-2008

Drug Decision Summary
(PDF, 96KB)

fampridine

Fampyra®

Multiple Sclerosis, improve walking ability

20-Jun-2013

Drug Decision Summary
(PDF, 109KB)

fesoterodine fumarate

Toviaz

Overactive Bladder

4-Aug-2016

Drug Decision Summary and DBC Reasons and Recommendations
(PDF, 309KB)

fidaxomicin

Dificid®

Clostridium difficile infection

25-Feb-2014

Drug Decision Summary
(PDF, 323KB)

filgrastim

Grastofil®

Prevention/treatment of neutropenia

31-Jan-2017

Drug Decision Summary
(PDF, 326KB)

filgrastim

Neupogen ®

Primary prophylaxis of febrile neutropenia for regimens where the risk of febrile neutropenia is equal to or greater than 20% and a line extension for pre-filled syringes

31-Jan-2017

Drug Decision Summary
(PDF, 325KB)

filgrastim

Grastofil®

Pre-filled sterile solution for injection

31-Jan-2017 

Drug Decision Summary
 (PDF, 325KB)

fluticasone furoate

Arnuity™Ellipta®

Asthma

13-Sep-2016

Drug Decision Summary
(PDF, 329KB)

fluticasone furoate-vilanterol

Breo® Ellipta®

Chronic Obstructive Pulmonary Disease (COPD)

15-May-2015

Drug Decision Summary
(PDF, 358KB)

fluticasone-vilanterol

Breo® Ellipta®

Asthma

13-Sep-2016

Drug Decision Summary
(PDF, 332KB)

fosfomycin

Monurol®

treatment of uncomplicated urinary tract infections

24-Mar-2015

Drug Decision Summary
(PDF, 357KB)

golimumab

Simponi

Ulcerative colitis

31-May-2016

Drug Decision Summary
(PDF, 322KB)

golimumab

Simponi® Intravenous (IV)

Rheumatoid Arthritis (RA)

31-May-2016

Drug Decision Summary
(PDF, 330KB)

gliclazide

Diamicron®

type 2 diabetes

08-Jul-2008

Drug Decision Summary
(PDF, 67KB)

grass pollen allergen extract

Oralair™

allergic rhinitis (grass pollen)

31-Oct-2013

Drug Decision Summary
(PDF, 101KB)

glycopyrronium

Seebri®

Chronic Obstructive Pulmonary Disease (COPD), maintenance bronchodilator treatment

19-Sep-2013

Drug Decision Summary
(PDF, 239KB)

imiquimod

Aldara®

actinic keratosis on the face or balding scalp

28-Jun-2010

Drug Decision Summary
(PDF, 459KB)

indacaterol

Onbrez®

Chronic Obstructive Pulmonary Disease (COPD), maintenance bronchodilator treatment

30-May-2013

Drug Decision Summary
(PDF, 109KB)

indacaterol-glycopyrronium

Ultibro® Breezhaler®

Chronic Obstructive Pulmonary Disease (COPD)

02-Jun-2015

Drug Decision Summary
(PDF, 322KB)

infliximab

Inflectra™

Ankylosing spondylitis, plaque psoriasis, psoriatic arthritis, rheumatoid arthritis

19-Feb-2016

Drug Decision Summary
(PDF, 326KB)

infliximab

Inflectra ®

Crohn’s disease and ulcerative colitis

1-Nov-2016

Drug Decision Summary
(PDF, 125KB)

ingenol mebutate

Picato®

Keratosis, actinic

05-Jun-2014

Drug Decision Summary
(PDF, 327KB)

insulin glulisine

Apidra™

type 1 or type 2 diabetes mellitus

01-Jun-2009

Drug Decision Summary
(PDF, 67KB)

interferon beta-1a

Rebif®

Clinically Isolated Syndrome (MS)

25-Mar-2014

Drug Decision Summary
(PDF, 319KB)

interferon beta-1b injection

Betaseron®

early treatment before a definite diagnosis of multiple sclerosis

23-Dec-2008

Drug Decision Summary
(PDF, 69KB)

isotretinoin

Epuris™

Treatment of severe acne

10-Oct-2013

Drug Decision Summary
(PDF, 106KB)

ivacaftor

Kalydeco™

cystic fibrosis (CF) in patients with G551D mutation

11-Mar-2015

Drug Decision Summary
(PDF, 361KB)

ivermectin

Rosiver™

inflammatory lesions of rosacea in adults 18 years of age and older

27-Sep-2016

Drug Decision Summary
(PDF, 126KB)

ledipasvir-sofosbuvir

Harvoni™

chronic hepatitis C (CHC) infection genotype 1 infection

24-Mar-2015

Drug Decision Summary
(PDF, 361KB)

levodopa + carbidopa + entacapone

Stalevo®

hard-to-treat Parkinson’s Disease

05-Jun-2009

Drug Decision Summary
(PDF, 103KB)

levofloxacin

Levaquin®

short-course airway infections

14-Jan-2009

Drug Decision Summary
(PDF, 475KB)

linagliptin; linagliptin-metformin

Trajenta®; Jentadueto™

Type 2 Diabetes Mellitus (T2DM)

05-Aug-2014

Drug Decision Summary
(PDF, 399KB)

lomitapide

Juxtapid

To reduce high cholesterol caused by homozygous familial hypercholesterolemia (HoFH)

23-Jun-2015

Drug Decision Summary
(PDF, 361KB)

lumacaftor-ivacaftor

Orkambi

cystic fibrosis (CF) in patients with F508del mutation

21-Mar-2017

Drug Decision Summary
(PDF, 324KB)

lovastatin + niacin

Advicor®

high cholesterol

03-Mar-2008

Drug Decision Summary
(PDF, 66KB)

lurasidone

Latuda™

schizophrenia

19-Sep-2013

Drug Decision Summary
(PDF, 285KB)

lurasidone

Latuda

schizophrenia

16-Sep-2014

Drug Decision Summary
(PDF, 326KB)

macitentan

Opsumit™

Pulmonary arterial hypertension

26-Jan-2016

=

Drug Decision Summary
(PDF, 329KB)

mirabegron

Myrbetriq

Overactive Bladder

4-Aug-2016

Drug Decision Summary and DBC Reasons and Recommendations
(PDF, 309KB)

moxifloxacin

Avelox®

airway infections

15-Jan-2009

Drug Decision Summary
(PDF, 559KB)

nebivolol

Bystolic®

Hypertension, essential

25-Mar-2014

Drug Decision Summary
(PDF, 320KB)

ocriplasmin

Jetrea®

symptomatic vitreomacular adhesion

27-Jan-2015

Drug Decision Summary
(PDF, 319KB)

omalizumab

Xolair ®

Chronic idiopathic urticarial

29-Nov-2016

Drug Decision Summary
(PDF, 320KB)

ombitasvir-paritaprevir-ritonavir and dasabuvir

Holkira™Pak

Chronic Hepatitis C (CHC) genotype 1 infection

28-Jul-2015

Drug Decision Summary
(PDF, 362KB)

onabotulinumtoxinA

Botox®

Prevention of headaches in adults with chronic migraine

18-Nov-2014

Drug Decision Summary
(PDF, 320KB)

oxybutynin (controlled-release)

Uromax®

overactive bladder

27-Feb-2008

Drug Decision Summary
(PDF, 66KB)

overactive bladder

various drugs

Overactive Bladder

4-Aug-2016

Drug Decision Summary and DBC Reasons and Recommendations
(PDF, 309KB)

overactive bladder therapeutic review

N/A

overactive bladder

N/A

DBC Reasons and Recommendations
(PDF, 195KB)

overactive bladder therapeutic review

N/A

overactive bladder

N/A

Clinical Evidence Report 
(PDF, 4.746MB)

overactive bladder therapeutic review

N/A

overactive bladder

N/A

Pharmacoeconomic Evidence Report
(PDF, 485KB)

palonosetron hydrochloride

Aloxi® capsule

nausea and vomiting (chemotherapy induced) prevention

31-Oct-2013

Drug Decision Summary
(PDF, 103KB)

palonosetron hydrochloride

Aloxi® injection

nausea and vomiting (chemotherapy induced) prevention

31-Oct-2013

Drug Decision Summary
(PDF, 100KB)

pasireotide

Signifor®

treatment of adult patients with Cushing's disease for whom medical therapy is appropriate

01-Sep-2015

Drug Decision Summary
(PDF, 360KB)

peginterferon beta-1a

Plegridy

Multiple Sclerosis (MS), relapsing

4-Aug-2016

Drug Decision Summary
(PDF, 325KB)

pegvisomant

Esbriet®

Pulmonary fibrosis (idiopathic, mild to moderate)

14-Jan-2014

Drug Decision Summary
(PDF, 102KB)

perampanel

Fycompa™

Epilepsy, partial onset seizures

15-Aug-2014

Drug Decision Summary
(PDF, 330KB)

pirfenidone

Somavert®

last line of treatment for acromegaly

14-Jan-2014

Drug Decision Summary
(PDF, 323KB)

ramipril + hydrochlorothiazide

Altace HCT®

hypertension

17-Dec-2008

Drug Decision Summary
(PDF, 65KB)

riociguat

Adempas®

Chronic thromboembolic pulmonary hypertension (CTEPH)

10-Mar-2015

Drug Decision Summary
(PDF, 359KB)

riociguat

Adempas®

Pulmonary Arterial Hypertension (PAH)

2-May-2017

Drug Decision Summary
(PDF, 322KB)

rivaroxaban

Xarelto®

Thromboembolic events (venous), pulmonary embolism (PE)

30-Sep-2014

Drug Decision Summary
(PDF, 328KB)

rotigotine

Neupro®

Treatment of idiopathic Parkinson Disease (PD)

18-Nov-2014

Drug Decision Summary
(PDF, 358KB)

saxagliptin; saxagliptin-metformin

Onglyza®; Komboglyze™

Type 2 Diabetes Mellitus (T2DM)

05-Aug-2014

Drug Decision Summary
(PDF, 399KB)

secukinumab

Cosentyx

Psoriasis, moderate to severe plaque

28-Jul-16

Drug Decision Summary
(PDF, 309KB)

simeprevir

Galexos™

chronic hepatitis C (CHC) genotype 1 infection

28-Oct-2014

Drug Decision Summary
(PDF, 364KB)

sitagliptin; sitagliptin-metformin

Januvia®; Janumet®; Janumet® XR

Type 2 Diabetes Mellitus (T2DM)

05-Aug-2014

Drug Decision Summary
(PDF, 399KB)

sofosbuvir

Sovaldi®

chronic hepatitis C (CHC) infection

24-Mar-2015

Drug Decision Summary
(PDF, 364KB)

sofosbuvir-velpatasvir

Epclusa™

Chronic Hepatitis C (CHC)

21-Mar-2017

Drug Decision Summary (PDF, 355KB)

somatropin

Genotropin®

Growth Hormone Deficiency, Adults

05-Aug-2014

Drug Decision Summary
(PDF, 328KB)

somatropin

Genotropin®

Growth Hormone Deficiency, Pediatrics

05-Aug-2014

Drug Decision Summary
(PDF, 329KB)

somatropin

Genotropin®

Growth Hormone Deficiency, Turner Syndrome

05-Aug-2014

Drug Decision Summary
(PDF, 328KB)

stiripentol

Diacomit

Severe myoclonic epilepsy in infancy (Dravet syndrome)

07-Jul-2015

Drug Decision Summary
(PDF, 360KB)

telaprevir

Incivek®

Chronic Hepatitis C virus infection in patients co-infected with HIV

10-Oct-2013

Drug Decision Summary
(PDF, 360KB)

telbivudine

Sebivo®

chronic hepatitis B infection in patients with liver disease

27-Mar-2008

Drug Decision Summary
(PDF, 138KB)

teriflunomide

Aubagio™

Relapsing-Remitting Multiple Sclerosis (RRMS)

09-Dec-2014

Drug Decision Summary
(PDF, 361KB)

tesamorelin

Egrifta®

Excess visceral adipose tissue (VAT) in treatment-experienced adult human immunodeficiency virus (HIV)-infected patients with lipodystrophy

13-Dec-2016

Drug Decision Summary
(PDF, 319KB)

tinzaparin

Innohep ®

Venous thromboembolism (VTE) associated with cancer

14-Feb-2017

Drug Decision Summary
(PDF, 326KB)

tiotropium-olodaterol

Inspiolto™ Respimat®

Chronic Obstructive Pulmonary Disease (COPD)

5-Apr-2016

Drug Decision Summary
(PDF, 326KB)

tiotropium bromide

Spiriva® Respimat®

Chronic Obstructive Pulmonary Disease (COPD)

5-Apr-2016

Drug Decision Summary
(PDF, 324KB)

tocilizumab

Actemra®

Moderate to severely active polyarticular Juvenile Idiopathic Arthritis (pJIA)

09-Dec-2014

Drug Decision Summary
(PDF, 365KB)

tocilizumab

Actemra®

Rheumatoid Arthritis

19-Feb-2016

Drug Decision Summary
(PDF, 325KB)

tofacitinib

Xeljanz™

Rheumatoid Arthritis

31-Jan-2017

Drug Decision Summary
(PDF, 321KB)

tolvaptan

Samsca®

Hyponatremia, non-hypovolemic

15-Aug-2013

Drug Decision Summary
(PDF, 108KB)

umeclidinium

Incruse™ Ellipta®

Chronic obstructive pulmonary disease (COPD)

16-Mar-2016

Drug Decision Summary
(PDF, 324KB)

umeclidinium-vilanterol

Anoro™ Ellipta™

Chronic obstructive pulmonary disease (COPD)

11-Aug-2015

Drug Decision Summary
(PDF, 360KB)

ustekinumab

Stelara®

treatment of moderate to severe psoriatic arthritis (PsA)

 26-May-2015

Drug Decision Summary
(PDF, 362KB)

vedolizumab

Entyvio™

Ulcerative Colitis

2-May-2017

Drug Decision Summary 
(PDF, 
122KB)